Expression of VARS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Valyl-tRNA synthetase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA046710

GENE INFORMATION
Gene name	VARS (HGNC Symbol)
Synonyms	VARS2
Description	Valyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary	Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31777518 - 31795953
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204394 (version 83.38)
Entrez gene	7407
UniProt	P26640 (UniProt - Evidence at protein level)
neXtProt	NX_P26640
Antibodypedia	VARS antibodies

PROTEIN BROWSER

VARS-001	VARS-002	VARS-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VARS-001 ENSP00000364815 ENST00000375663	P26640 [Direct mapping] Valine--tRNA ligase A0A024RCN6 [Target identity:100%; Query identity:100%] Valyl-tRNA synthetase, isoform CRA_a Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0002161 [aminoacyl-tRNA editing activity] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] GO:0006450 [regulation of translational fidelity] GO:0010467 [gene expression] Show all	1264 aa 140.5 kDa	No	0
VARS-002 ENSP00000413925 ENST00000440048	A2ABF4 [Direct mapping] Valine--tRNA ligase Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006438 [valyl-tRNA aminoacylation] Show all	174 aa 18.1 kDa	No	0
VARS-006 ENSP00000415679 ENST00000428445	H0Y426 [Direct mapping] Valine--tRNA ligase Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004832 [valine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006438 [valyl-tRNA aminoacylation] Show all	288 aa 32.4 kDa	No	0