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BAG6

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GENERAL INFORMATION

Gene name

 BAG6

Gene description

 BCL2-associated athanogene 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 22
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated), Cytosol (validated)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB020704 , HPA053291
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (validated), Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB020704 A-431 Cytosol
CAB020704 U-2 OS Nucleoplasm
Cytosol
CAB020704 U-251 MG Nucleoplasm
Cytosol
HPA053291 A-431 Nucleoplasm
Cytosol
HPA053291 U-2 OS Nucleoplasm
Vesicles
HPA053291 U-251 MG Nucleoplasm
Cytosol

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000024392 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA053291 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 BAG6 (HGNC Symbol)

Synonyms

 BAT3, D6S52E, G3

Description

 BCL2-associated athanogene 6 (HGNC Symbol)

Entrez gene summary

 This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31639028 - 31652705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204463 (version 83.38)

Entrez gene

 7917

UniProt

 P46379 (UniProt - Evidence at protein level)

neXtProt

 NX_P46379

Antibodypedia

 BAG6 antibodies

PROTEIN BROWSER
«
BAG6-001
BAG6-003
BAG6-004
BAG6-005
BAG6-006
BAG6-007
BAG6-010
BAG6-011
BAG6-013
BAG6-014
BAG6-015
BAG6-016
BAG6-017
BAG6-018
BAG6-019
BAG6-021
BAG6-024
BAG6-028
BAG6-030
BAG6-203
BAG6-204
BAG6-205
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BAG6-001
ENSP00000211379
ENST00000211379
P46379 [Direct mapping]
Large proline-rich protein BAG6
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006810 [transport]
GO:0007130 [synaptonemal complex assembly]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0009790 [embryo development]
GO:0016020 [membrane]
GO:0016568 [chromatin modification]
GO:0018393 [internal peptidyl-lysine acetylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043022 [ribosome binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045861 [negative regulation of proteolysis]
GO:0050821 [protein stabilization]
GO:0051787 [misfolded protein binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070628 [proteasome binding]
GO:0071816 [tail-anchored membrane protein insertion into ER membrane]
GO:0071818 [BAT3 complex]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904379 [protein localization to cytosolic proteasome complex involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 1126 aa
118.7 kDa 		No 0
BAG6-003
ENSP00000365143
ENST00000375976
P46379 [Direct mapping]
Large proline-rich protein BAG6
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006810 [transport]
GO:0007130 [synaptonemal complex assembly]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0009790 [embryo development]
GO:0016020 [membrane]
GO:0016568 [chromatin modification]
GO:0018393 [internal peptidyl-lysine acetylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043022 [ribosome binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045861 [negative regulation of proteolysis]
GO:0050821 [protein stabilization]
GO:0051787 [misfolded protein binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070628 [proteasome binding]
GO:0071816 [tail-anchored membrane protein insertion into ER membrane]
GO:0071818 [BAT3 complex]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904379 [protein localization to cytosolic proteasome complex involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 1126 aa
118.7 kDa 		No 0
BAG6-004
ENSP00000397978
ENST00000437771
X6REW1 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 743 aa
76.5 kDa 		No 0
BAG6-005
ENSP00000411083
ENST00000435080
F6S6P2 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 515 aa
54.7 kDa 		No 0
BAG6-006
ENSP00000411043
ENST00000424480
F6VEM6 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 258 aa
27.5 kDa 		No 0
BAG6-007
ENSP00000391613
ENST00000451898
F6WML8 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 244 aa
26 kDa 		No 0
BAG6-010
ENSP00000401031
ENST00000456622
F6WML8 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 244 aa
26 kDa 		No 0
BAG6-011
ENSP00000391783
ENST00000424176
F6XTU0 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 215 aa
23.1 kDa 		No 0
BAG6-013
ENSP00000404971
ENST00000452994
F6U341 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 262 aa
27.9 kDa 		No 0
BAG6-014
ENSP00000413561
ENST00000428326
F6U341 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 262 aa
27.9 kDa 		No 0
BAG6-015
ENSP00000396503
ENST00000454165
F6TC96 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 158 aa
16.7 kDa 		No 0
BAG6-016
ENSP00000406436
ENST00000456286
F6UR09 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 197 aa
21.2 kDa 		No 0
BAG6-017
ENSP00000388244
ENST00000433828
F6X9W3 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 259 aa
27.6 kDa 		No 0
BAG6-018
ENSP00000394856
ENST00000434444
F6WML8 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 244 aa
26 kDa 		No 0
BAG6-019
ENSP00000406302
ENST00000441054
F6U1F2 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 206 aa
22.1 kDa 		No 0
BAG6-021
ENSP00000406434
ENST00000453833
H0Y7K4 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 185 aa
18.8 kDa 		No 0
BAG6-024
ENSP00000410280
ENST00000438149
H0Y759 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 238 aa
23 kDa 		No 0
BAG6-028
ENSP00000416633
ENST00000441793
H0Y710 [Direct mapping]
Large proline-rich protein BAG6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 226 aa
24.7 kDa 		No 0
BAG6-030
ENSP00000413225
ENST00000422948
H0Y4L1 [Direct mapping]
Large proline-rich protein BAG6
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 136 aa
15.4 kDa 		No 0
BAG6-203
ENSP00000354875
ENST00000362049
P46379 [Direct mapping]
Large proline-rich protein BAG6
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006810 [transport]
GO:0007130 [synaptonemal complex assembly]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0009790 [embryo development]
GO:0016020 [membrane]
GO:0016568 [chromatin modification]
GO:0018393 [internal peptidyl-lysine acetylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043022 [ribosome binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045861 [negative regulation of proteolysis]
GO:0050821 [protein stabilization]
GO:0051787 [misfolded protein binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070628 [proteasome binding]
GO:0071816 [tail-anchored membrane protein insertion into ER membrane]
GO:0071818 [BAT3 complex]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904379 [protein localization to cytosolic proteasome complex involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 1077 aa
113.5 kDa 		No 0
BAG6-204
ENSP00000365131
ENST00000375964
P46379 [Direct mapping]
Large proline-rich protein BAG6
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006810 [transport]
GO:0007130 [synaptonemal complex assembly]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0009790 [embryo development]
GO:0016020 [membrane]
GO:0016568 [chromatin modification]
GO:0018393 [internal peptidyl-lysine acetylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0030544 [Hsp70 protein binding]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042127 [regulation of cell proliferation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043022 [ribosome binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045861 [negative regulation of proteolysis]
GO:0050821 [protein stabilization]
GO:0051787 [misfolded protein binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070628 [proteasome binding]
GO:0071816 [tail-anchored membrane protein insertion into ER membrane]
GO:0071818 [BAT3 complex]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904379 [protein localization to cytosolic proteasome complex involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 1132 aa
119.4 kDa 		No 0
BAG6-205
ENSP00000402856
ENST00000439687
P46379 [Direct mapping]
Large proline-rich protein BAG6
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006810 [transport]
GO:0007130 [synaptonemal complex assembly]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0009790 [embryo development]
GO:0016020 [membrane]
GO:0016568 [chromatin modification]
GO:0018393 [internal peptidyl-lysine acetylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0031593 [polyubiquitin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043022 [ribosome binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045861 [negative regulation of proteolysis]
GO:0050821 [protein stabilization]
GO:0051787 [misfolded protein binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070628 [proteasome binding]
GO:0071816 [tail-anchored membrane protein insertion into ER membrane]
GO:0071818 [BAT3 complex]
GO:1904294 [positive regulation of ERAD pathway]
GO:1904378 [maintenance of unfolded protein involved in ERAD pathway]
GO:1904379 [protein localization to cytosolic proteasome complex involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 903 aa
96.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.