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AIF1

GENERAL INFORMATION

Gene name

 AIF1

Gene description

 Allograft inflammatory factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA049234
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AIF1 (HGNC Symbol)

Synonyms

 AIF-1, Em:AF129756.17, IBA1, IRT-1

Description

 Allograft inflammatory factor 1 (HGNC Symbol)

Entrez gene summary

 This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31615184 - 31617021

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204472 (version 83.38)

Entrez gene

 199

UniProt

 P55008 (UniProt - Evidence at protein level)

neXtProt

 NX_P55008

Antibodypedia

 AIF1 antibodies

PROTEIN BROWSER
AIF1-001
AIF1-002
AIF1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AIF1-001
ENSP00000365227
ENST00000376059
P55008 [Direct mapping]
Allograft inflammatory factor 1
Q4V347 [Target identity:100%; Query identity:100%]
Allograft inflammatory factor 1 isoform 3; Allograft inflammatory factor 1, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0001774 [microglial cell activation]
GO:0001891 [phagocytic cup]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003674 [molecular_function]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006911 [phagocytosis, engulfment]
GO:0006954 [inflammatory response]
GO:0010629 [negative regulation of gene expression]
GO:0014739 [positive regulation of muscle hyperplasia]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0030335 [positive regulation of cell migration]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032587 [ruffle membrane]
GO:0032870 [cellular response to hormone stimulus]
GO:0034097 [response to cytokine]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043204 [perikaryon]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0048678 [response to axon injury]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051384 [response to glucocorticoid]
GO:0051602 [response to electrical stimulus]
GO:0071315 [cellular response to morphine]
GO:0071346 [cellular response to interferon-gamma]
GO:0071447 [cellular response to hydroperoxide]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097178 [ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000406 [positive regulation of T cell migration]
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 147 aa
16.7 kDa 		No 0
AIF1-002
ENSP00000365217
ENST00000376049
P55008 [Direct mapping]
Allograft inflammatory factor 1
I3WTX1 [Target identity:100%; Query identity:100%]
Allograft inflammatory factor 1 isoform 1; Allograft inflammatory factor 1, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001774 [microglial cell activation]
GO:0001891 [phagocytic cup]
GO:0003674 [molecular_function]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006911 [phagocytosis, engulfment]
GO:0006954 [inflammatory response]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0032587 [ruffle membrane]
GO:0042102 [positive regulation of T cell proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0071346 [cellular response to interferon-gamma]
GO:0071672 [negative regulation of smooth muscle cell chemotaxis]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097178 [ruffle assembly]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000406 [positive regulation of T cell migration]
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 93 aa
10.5 kDa 		No 0
AIF1-004
ENSP00000338776
ENST00000337917
Q5STX8 [Direct mapping]
Allograft inflammatory factor 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
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 161 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.