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Cancer tissues displayed moderate to strong cytoplasmic staining with additional membranous positivity in several cases. Several cases of lymphomas, prostate, endometrial, cervical, breast and renal cancers were weakly stained or negative.
Cancer tissues displayed moderate cytoplasmic and occasional nuclear positivity. Rare cases of hepatocellular carcinomas and endometrial cancers displayed strong staining. Lymphomas, lung, skin and testicular cancers were weakly stained or negative.
The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C. [provided by RefSeq, Jul 2008]