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A heterogeneous pattern was observed among cancers. Most tumor cells showed moderate to strong cytoplasmic positivity. Most skin and testicular cancers along with several breast, lung, endometrial and prostate cancers were weakly stained or negative.
Lymphomas and several melanomas displayed moderate to strong cytoplasmic staining. A majority of colorectal, cervical, endometrial and skin cancers displayed moderate cytoplasmic staining. Remaining cancers were in general weakly stained or negative.
GENE INFORMATION
Gene name
HLA-E
Synonyms
Description
Major histocompatibility complex, class I, E (HGNC Symbol)
Entrez gene summary
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Q6DU44 [Direct mapping] HLA class I histocompatibility antigen, alpha chain E; HLA-E protein; MHC class I antigen; MHC class Ib antigen; Major histocompatibility complex, class I, E
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]
