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Major histocompatibility complex, class I, E (HGNC Symbol)
Entrez gene summary
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Q6DU44 [Direct mapping] HLA class I histocompatibility antigen, alpha chain E; HLA-E protein; MHC class I antigen; MHC class Ib antigen; Major histocompatibility complex, class I, E
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]
