Tissue expression of TRIM40 - Summary - The Human Protein Atlas

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TRIM40

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TRIM40
Gene description	Tripartite motif containing 40
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Group enriched (small intestine, testis, colon, liver)
FANTOM5:	Group enriched (placenta, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA043818
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (small intestine, testis, colon, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (placenta, small intestine)

GENE INFORMATION
Gene name	TRIM40 (HGNC Symbol)
Synonyms	RNF35
Description	Tripartite motif containing 40 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Feb 2014]
Chromosome	6
Cytoband	p22.1
Chromosome location (bp)	30136108 - 30148735
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204614 (version 83.38)
Entrez gene	135644
UniProt	Q6P9F5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P9F5
Antibodypedia	TRIM40 antibodies

PROTEIN BROWSER

TRIM40-001	TRIM40-002	TRIM40-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM40-001 ENSP00000379826 ENST00000396581	Q6P9F5 [Direct mapping] Tripartite motif-containing protein 40 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0008385 [IkappaB kinase complex] GO:0030308 [negative regulation of cell growth] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0042177 [negative regulation of protein catabolic process] GO:0045116 [protein neddylation] GO:1900181 [negative regulation of protein localization to nucleus] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] Show all	258 aa 29.3 kDa	No	0
TRIM40-002 ENSP00000308310 ENST00000307859	Q6P9F5 [Direct mapping] Tripartite motif-containing protein 40 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0008385 [IkappaB kinase complex] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0042177 [negative regulation of protein catabolic process] GO:0045116 [protein neddylation] GO:1900181 [negative regulation of protein localization to nucleus] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] Show all	229 aa 26.1 kDa	No	0
TRIM40-202 ENSP00000365914 ENST00000376724	Q6P9F5 [Direct mapping] Tripartite motif-containing protein 40 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0008385 [IkappaB kinase complex] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0042177 [negative regulation of protein catabolic process] GO:0045116 [protein neddylation] GO:1900181 [negative regulation of protein localization to nucleus] GO:1901223 [negative regulation of NIK/NF-kappaB signaling] Show all	258 aa 29.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.