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Weak to moderate cytoplasmic and/or occasional nuclear positivity was displayed in papillary adenocarcinomas of thyroid, several melanomas along with few liver, pancreatic, stomach and renal cancers. Remaining cancer tissues were negative.
Gliomas as well as cases of melanomas, colorectal, ovarian, endometrial and testicular cancers exhibited weak to moderate cytoplasmic immunoreactivity. Remaining cancers were mainly negative.
GENE INFORMATION
Gene name
RNF39 (HGNC Symbol)
Synonyms
HZFw1, LIRF
Description
Ring finger protein 39 (HGNC Symbol)
Entrez gene summary
This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
