Expression of PPP1R11 in cancer - Summary

CANCER ATLAS

Gene description

Protein phosphatase 1, regulatory (inhibitor) subunit 11

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043266

GENE INFORMATION
Gene name	PPP1R11 (HGNC Symbol)
Synonyms	CFAP255, HCG-V, HCGV, TCTE5, Tctex5
Description	Protein phosphatase 1, regulatory (inhibitor) subunit 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.1
Chromosome location (bp)	30066709 - 30070333
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204619 (version 83.38)
Entrez gene	6992
UniProt	O60927 (UniProt - Evidence at protein level)
neXtProt	NX_O60927
Antibodypedia	PPP1R11 antibodies

PROTEIN BROWSER

PPP1R11-001	PPP1R11-002	PPP1R11-003	PPP1R11-004	PPP1R11-005	PPP1R11-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R11-001 ENSP00000365960 ENST00000376769	Q5SRK2 [Direct mapping] PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0008157 [protein phosphatase 1 binding] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0035308 [negative regulation of protein dephosphorylation] Show all	74 aa 8.2 kDa	No	0
PPP1R11-002 ENSP00000365963 ENST00000376772	O60927 [Direct mapping] Protein phosphatase 1 regulatory subunit 11 A2BEK1 [Target identity:100%; Query identity:100%] Protein phosphatase 1, regulatory (Inhibitor) subunit 11, isoform CRA_a; cDNA, FLJ93673, Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit11 (PPP1R11), transcript variant 1, mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008157 [protein phosphatase 1 binding] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0035308 [negative regulation of protein dephosphorylation] Show all	126 aa 14 kDa	No	0
PPP1R11-003 ENSP00000365949 ENST00000376758	Q5SRK2 [Direct mapping] PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0008157 [protein phosphatase 1 binding] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0035308 [negative regulation of protein dephosphorylation] Show all	74 aa 8.2 kDa	No	0
PPP1R11-004 ENSP00000365964 ENST00000376773	Q5SRK2 [Direct mapping] PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0008157 [protein phosphatase 1 binding] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0035308 [negative regulation of protein dephosphorylation] Show all	74 aa 8.2 kDa	No	0
PPP1R11-005 ENSP00000365954 ENST00000376763	Q5SRK2 [Direct mapping] PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0008157 [protein phosphatase 1 binding] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0035308 [negative regulation of protein dephosphorylation] Show all	74 aa 8.2 kDa	No	0
PPP1R11-006 ENSP00000365956 ENST00000376765	Q5SRK2 [Direct mapping] PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0004865 [protein serine/threonine phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0008157 [protein phosphatase 1 binding] GO:0032515 [negative regulation of phosphoprotein phosphatase activity] GO:0035308 [negative regulation of protein dephosphorylation] Show all	74 aa 8.2 kDa	No	0