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PPP1R11

GENERAL INFORMATION

Gene name

 PPP1R11

Gene description

 Protein phosphatase 1, regulatory (inhibitor) subunit 11

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (epididymis)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA043266
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPP1R11 (HGNC Symbol)

Synonyms

 CFAP255, HCG-V, HCGV, TCTE5, Tctex5

Description

 Protein phosphatase 1, regulatory (inhibitor) subunit 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 30066709 - 30070333

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204619 (version 83.38)

Entrez gene

 6992

UniProt

 O60927 (UniProt - Evidence at protein level)

neXtProt

 NX_O60927

Antibodypedia

 PPP1R11 antibodies

PROTEIN BROWSER
PPP1R11-001
PPP1R11-002
PPP1R11-003
PPP1R11-004
PPP1R11-005
PPP1R11-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R11-001
ENSP00000365960
ENST00000376769
Q5SRK2 [Direct mapping]
PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0008157 [protein phosphatase 1 binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0035308 [negative regulation of protein dephosphorylation]
Show all
 74 aa
8.2 kDa 		No 0
PPP1R11-002
ENSP00000365963
ENST00000376772
O60927 [Direct mapping]
Protein phosphatase 1 regulatory subunit 11
A2BEK1 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 11, isoform CRA_a; cDNA, FLJ93673, Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit11 (PPP1R11), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008157 [protein phosphatase 1 binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0035308 [negative regulation of protein dephosphorylation]
Show all
 126 aa
14 kDa 		No 0
PPP1R11-003
ENSP00000365949
ENST00000376758
Q5SRK2 [Direct mapping]
PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0008157 [protein phosphatase 1 binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0035308 [negative regulation of protein dephosphorylation]
Show all
 74 aa
8.2 kDa 		No 0
PPP1R11-004
ENSP00000365964
ENST00000376773
Q5SRK2 [Direct mapping]
PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0008157 [protein phosphatase 1 binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0035308 [negative regulation of protein dephosphorylation]
Show all
 74 aa
8.2 kDa 		No 0
PPP1R11-005
ENSP00000365954
ENST00000376763
Q5SRK2 [Direct mapping]
PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0008157 [protein phosphatase 1 binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0035308 [negative regulation of protein dephosphorylation]
Show all
 74 aa
8.2 kDa 		No 0
PPP1R11-006
ENSP00000365956
ENST00000376765
Q5SRK2 [Direct mapping]
PPP1R11 protein; Protein phosphatase 1 regulatory subunit 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005634 [nucleus]
GO:0008157 [protein phosphatase 1 binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0035308 [negative regulation of protein dephosphorylation]
Show all
 74 aa
8.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.