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Most malignant cells displayed weak to moderate nuclear and cytoplasmic positivity. Several cases of malignant lymphomas, renal and liver cancers were negative.
GENE INFORMATION
Gene name
LGR4 (HGNC Symbol)
Synonyms
GPR48
Description
Leucine-rich repeat containing G protein-coupled receptor 4 (HGNC Symbol)
Entrez gene summary
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008]