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SNX2

CANCER ATLAS

Gene description

 Sorting nexin 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037400

GENE INFORMATION

Gene name

 SNX2

Synonyms

Description

 Sorting nexin 2 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q23.2

Chromosome location (bp)

 122774996 - 122830108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205302 (version 83.38)

Entrez gene

 6643

UniProt

 O60749 (UniProt - Evidence at protein level)

neXtProt

 NX_O60749

Antibodypedia

 SNX2 antibodies

PROTEIN BROWSER
SNX2-001
SNX2-011
SNX2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX2-001
ENSP00000368831
ENST00000379516
O60749 [Direct mapping]
Sorting nexin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
Show all
 519 aa
58.5 kDa 		No 0
SNX2-011
ENSP00000421663
ENST00000514949
O60749 [Direct mapping]
Sorting nexin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
Show all
 402 aa
46.1 kDa 		No 0
SNX2-012
ENSP00000422413
ENST00000505934
D6RC15 [Direct mapping]
Sorting nexin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030904 [retromer complex]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 266 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.