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SNX2

GENERAL INFORMATION

Gene name

 SNX2

Gene description

 Sorting nexin 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA037400
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SNX2

Synonyms

Description

 Sorting nexin 2 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q23.2

Chromosome location (bp)

 122774996 - 122830108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205302 (version 83.38)

Entrez gene

 6643

UniProt

 O60749 (UniProt - Evidence at protein level)

neXtProt

 NX_O60749

Antibodypedia

 SNX2 antibodies

PROTEIN BROWSER
SNX2-001
SNX2-011
SNX2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX2-001
ENSP00000368831
ENST00000379516
O60749 [Direct mapping]
Sorting nexin-2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
Show all
 519 aa
58.5 kDa 		No 0
SNX2-011
ENSP00000421663
ENST00000514949
O60749 [Direct mapping]
Sorting nexin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
Show all
 402 aa
46.1 kDa 		No 0
SNX2-012
ENSP00000422413
ENST00000505934
D6RC15 [Direct mapping]
Sorting nexin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030904 [retromer complex]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 266 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.