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Several pancreas, gastric and urothelial cancers showed moderate cytoplasmic positivity. The remaining malignancies were in general negative or weakly stained.
GENE INFORMATION
Gene name
ITSN1 (HGNC Symbol)
Synonyms
ITSN, MGC134948, MGC134949, SH3D1A, SH3P17
Description
Intersectin 1 (SH3 domain protein) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]