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ITSN1

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GENERAL INFORMATION

Gene name

 ITSN1

Gene description

 Intersectin 1 (SH3 domain protein)

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 18
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA018007
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA018007 A-431 Plasma membrane
HPA018007 U-2 OS Plasma membrane
HPA018007 U-251 MG Plasma membrane

GENE INFORMATION

Gene name

 ITSN1 (HGNC Symbol)

Synonyms

 ITSN, MGC134948, MGC134949, SH3D1A, SH3P17

Description

 Intersectin 1 (SH3 domain protein) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 33642400 - 33899861

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205726 (version 83.38)

Entrez gene

 6453

UniProt

 Q15811 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15811

Antibodypedia

 ITSN1 antibodies

PROTEIN BROWSER
«
ITSN1-001
ITSN1-002
ITSN1-003
ITSN1-004
ITSN1-005
ITSN1-017
ITSN1-023
ITSN1-024
ITSN1-025
ITSN1-030
ITSN1-032
ITSN1-033
ITSN1-036
ITSN1-037
ITSN1-201
ITSN1-202
ITSN1-203
ITSN1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITSN1-001
ENSP00000370719
ENST00000381318
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0019209 [kinase activator activity]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030139 [endocytic vesicle]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0042327 [positive regulation of phosphorylation]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1721 aa
195.4 kDa 		No 0
ITSN1-002
ENSP00000370691
ENST00000381291
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1220 aa
137.6 kDa 		No 0
ITSN1-003
ENSP00000382286
ENST00000399349
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1144 aa
129.4 kDa 		No 0
ITSN1-004
ENSP00000370684
ENST00000381284
H0Y3G5 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 317 aa
36.2 kDa 		No 0
ITSN1-005
ENSP00000409800
ENST00000415023
Q6J334 [Direct mapping]
Intersectin 1 isoform 10; Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 173 aa
19.8 kDa 		No 0
ITSN1-017
ENSP00000411464
ENST00000456489
H7C3F1 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 60 aa
6.3 kDa 		No 0
ITSN1-023
ENSP00000382301
ENST00000399367
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1716 aa
194.8 kDa 		No 0
ITSN1-024
ENSP00000382289
ENST00000399352
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1215 aa
137 kDa 		No 0
ITSN1-025
ENSP00000382290
ENST00000399353
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1178 aa
133.6 kDa 		No 0
ITSN1-030
ENSP00000396054
ENST00000440794
H0Y523 [Direct mapping]
Intersectin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 260 aa
28.1 kDa 		No 1
ITSN1-032
ENSP00000407132
ENST00000451686
C9JXS9 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 78 aa
8.8 kDa 		No 0
ITSN1-033
ENSP00000400079
ENST00000444491
C9J1A4 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 115 aa
12.8 kDa 		No 0
ITSN1-036
ENSP00000370683
ENST00000381283
C9JQZ7 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 361 aa
41 kDa 		No 0
ITSN1-037
ENSP00000382292
ENST00000399355
F8W7U0 [Direct mapping]
Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
Show all
 1149 aa
130 kDa 		No 0
ITSN1-201
ENSP00000369294
ENST00000379960
D6PAW0 [Direct mapping]
Intersectin 1 short form A variant 3; Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 237 aa
25.1 kDa 		No 0
ITSN1-202
ENSP00000370685
ENST00000381285
A8CTZ0 [Direct mapping]
Intersectin 1 short form variant 13; Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 877 aa
100.7 kDa 		No 0
ITSN1-203
ENSP00000382275
ENST00000399338
Q15811 [Direct mapping]
Intersectin-1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0032947 [protein complex scaffold]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048488 [synaptic vesicle endocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070064 [proline-rich region binding]
GO:0097190 [apoptotic signaling pathway]
Show all
 1020 aa
115.9 kDa 		No 1
ITSN1-204
ENSP00000387377
ENST00000437442
D6PAW0 [Direct mapping]
Intersectin 1 short form A variant 3; Intersectin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 237 aa
25.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.