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Majority of the malignant tissues exhibited moderate cytoplasmic immunoreactivity. Thyroid cancers and several cases of endometrial cancers showed strong staining. Several cases of prostate, cervical, urothelial and renal cancers were weakly stained or negative.
This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]