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SERPINB5

GENERAL INFORMATION

Gene name

 SERPINB5

Gene description

 Serpin peptidase inhibitor, clade B (ovalbumin), member 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skin, esophagus)
GTEx:Tissue enhanced (skin, esophagus)
FANTOM5:Group enriched (esophagus, tonsil, cervix, uterine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with varying intensity in most tissues, most abundant in squamous epithelia and the gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 4 antibodies.
HPA019025 , HPA019132 , HPA020136 , CAB009570
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skin, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil, cervix, uterine)

GENE INFORMATION

Gene name

 SERPINB5 (HGNC Symbol)

Synonyms

 maspin, PI5

Description

 Serpin peptidase inhibitor, clade B (ovalbumin), member 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 q21.33

Chromosome location (bp)

 63476761 - 63505085

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000206075 (version 83.38)

Entrez gene

 5268

UniProt

 P36952 (UniProt - Evidence at protein level)

neXtProt

 NX_P36952

Antibodypedia

 SERPINB5 antibodies

PROTEIN BROWSER
SERPINB5-001
SERPINB5-002
SERPINB5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINB5-001
ENSP00000372221
ENST00000382771
P36952 [Direct mapping]
Serpin B5
A0A024R2B6 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade B (Ovalbumin), member 5, isoform CRA_b
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002009 [morphogenesis of an epithelium]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006928 [movement of cell or subcellular component]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030198 [extracellular matrix organization]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0060512 [prostate gland morphogenesis]
GO:0070062 [extracellular exosome]
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 375 aa
42.1 kDa 		No 0
SERPINB5-002
ENSP00000467158
ENST00000489441
P36952 [Direct mapping]
Serpin B5
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006928 [movement of cell or subcellular component]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0070062 [extracellular exosome]
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 231 aa
25.8 kDa 		No 0
SERPINB5-003
ENSP00000408821
ENST00000424602
C9JLM5 [Direct mapping]
Serpin B5
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 129 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.