Cell atlas - COLQ - The Human Protein Atlas

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COLQ

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	COLQ
Gene description	Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cell junctions.
RNA cell category	Cell line enhanced (BEWO, U-937, HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045876
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, U-937, HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cell junctions.

Main location

Plasma membrane (approved)

Additional location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045876	A-431	Plasma membrane
	HPA045876	A-431	Cell Junctions
	HPA045876	U-2 OS	Plasma membrane
	HPA045876	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	COLQ (HGNC Symbol)
Synonyms	EAD
Description	Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase (HGNC Symbol)
Entrez gene summary	This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	15450133 - 15521751
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206561 (version 83.38)
Entrez gene	8292
UniProt	Q9Y215 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y215
Antibodypedia	COLQ antibodies

PROTEIN BROWSER

COLQ-001	COLQ-002	COLQ-003	COLQ-004	COLQ-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COLQ-001 ENSP00000373298 ENST00000383788	Q9Y215 [Direct mapping] Acetylcholinesterase collagenic tail peptide Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0008105 [asymmetric protein localization] GO:0008582 [regulation of synaptic growth at neuromuscular junction] GO:0030054 [cell junction] GO:0031594 [neuromuscular junction] GO:0043083 [synaptic cleft] GO:0071340 [skeletal muscle acetylcholine-gated channel clustering] GO:0090150 [establishment of protein localization to membrane] Show all	455 aa 47.8 kDa	Yes	0
COLQ-002 ENSP00000474271 ENST00000603808	A0A0C4DGS2 [Direct mapping] Acetylcholinesterase collagenic tail peptide Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all		456 aa 47.9 kDa	Yes	0
COLQ-003 ENSP00000373291 ENST00000383781	Q9Y215 [Direct mapping] Acetylcholinesterase collagenic tail peptide Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0008105 [asymmetric protein localization] GO:0030054 [cell junction] GO:0043083 [synaptic cleft] Show all	445 aa 46.5 kDa	Yes	0
COLQ-004 ENSP00000474936 ENST00000605797	S4R408 [Direct mapping] Acetylcholinesterase collagenic tail peptide Show all	Predicted intracellular proteins Show all		194 aa 19.4 kDa	No	0
COLQ-007 ENSP00000373296 ENST00000383786	Q9Y215 [Direct mapping] Acetylcholinesterase collagenic tail peptide Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001507 [acetylcholine catabolic process in synaptic cleft] GO:0005515 [protein binding] GO:0005581 [collagen trimer] GO:0005605 [basal lamina] GO:0005615 [extracellular space] GO:0008105 [asymmetric protein localization] GO:0030054 [cell junction] GO:0043083 [synaptic cleft] Show all	421 aa 44.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.