Fields »
ABOUT
HELP
BLOG
DENND1B

GENERAL INFORMATION

Gene name

 DENND1B

Gene description

 DENN/MADD domain containing 1B

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA042586
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DENND1B (HGNC Symbol)

Synonyms

 C1orf218, FAM31B, FLJ20054, MGC27044

Description

 DENN/MADD domain containing 1B (HGNC Symbol)

Entrez gene summary

 Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

Chromosome

 1

Cytoband

 q31.3

Chromosome location (bp)

 197504748 - 197775696

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213047 (version 83.38)

Entrez gene

 163486

UniProt

 Q6P3S1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P3S1

Antibodypedia

 DENND1B antibodies

PROTEIN BROWSER
DENND1B-001
DENND1B-003
DENND1B-004
DENND1B-010
DENND1B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DENND1B-001
ENSP00000375839
ENST00000391979
X6RAS2 [Direct mapping]
DENN domain-containing protein 1B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 415 aa
45.8 kDa 		No 0
DENND1B-003
ENSP00000356366
ENST00000367396
Q6P3S1 [Direct mapping]
DENN domain-containing protein 1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0015031 [protein transport]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030136 [clathrin-coated vesicle]
GO:0043547 [positive regulation of GTPase activity]
Show all
 426 aa
48.3 kDa 		No 1
DENND1B-004
ENSP00000235453
ENST00000235453
Q6P3S1 [Direct mapping]
DENN domain-containing protein 1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0015031 [protein transport]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030136 [clathrin-coated vesicle]
GO:0043547 [positive regulation of GTPase activity]
Show all
 396 aa
44.9 kDa 		No 1
DENND1B-010
ENSP00000410025
ENST00000422998
B7ZBL5 [Direct mapping]
DENN domain-containing protein 1B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 147 aa
16.9 kDa 		No 0
DENND1B-201
ENSP00000479816
ENST00000620048
Q6P3S1 [Direct mapping]
DENN domain-containing protein 1B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0015031 [protein transport]
GO:0017112 [Rab guanyl-nucleotide exchange factor activity]
GO:0030136 [clathrin-coated vesicle]
GO:0043547 [positive regulation of GTPase activity]
Show all
 775 aa
86.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.