Expression of QTRT1 in cancer - Summary

CANCER ATLAS

Gene description

Queuine tRNA-ribosyltransferase 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA048651	HPA049440

GENE INFORMATION
Gene name	QTRT1 (HGNC Symbol)
Synonyms	TGT
Description	Queuine tRNA-ribosyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10701430 - 10713437
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213339 (version 83.38)
Entrez gene	81890
UniProt	Q9BXR0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXR0
Antibodypedia	QTRT1 antibodies

PROTEIN BROWSER

QTRT1-001	QTRT1-007	QTRT1-009	QTRT1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
QTRT1-001 ENSP00000250237 ENST00000250237	Q9BXR0 [Direct mapping] Queuine tRNA-ribosyltransferase Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008479 [queuine tRNA-ribosyltransferase activity] GO:0008616 [queuosine biosynthetic process] GO:0010467 [gene expression] GO:0046872 [metal ion binding] Show all	403 aa 44 kDa	No	0
QTRT1-007 ENSP00000468811 ENST00000592254	K7ESP6 [Direct mapping] Queuine tRNA-ribosyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006400 [tRNA modification] GO:0008479 [queuine tRNA-ribosyltransferase activity] GO:0008616 [queuosine biosynthetic process] Show all	180 aa 19.8 kDa	No	0
QTRT1-009 ENSP00000467394 ENST00000591643	K7EPI1 [Direct mapping] Queuine tRNA-ribosyltransferase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006400 [tRNA modification] GO:0008479 [queuine tRNA-ribosyltransferase activity] GO:0008616 [queuosine biosynthetic process] Show all	124 aa 13.4 kDa	No	0
QTRT1-011 ENSP00000465974 ENST00000592376	K7EL95 [Direct mapping] Queuine tRNA-ribosyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006400 [tRNA modification] GO:0008479 [queuine tRNA-ribosyltransferase activity] GO:0008616 [queuosine biosynthetic process] Show all	136 aa 14.9 kDa	No	0