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QTRT1

GENERAL INFORMATION

Gene name

 QTRT1

Gene description

 Queuine tRNA-ribosyltransferase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA048651 , HPA049440
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 QTRT1 (HGNC Symbol)

Synonyms

 TGT

Description

 Queuine tRNA-ribosyltransferase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10701430 - 10713437

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213339 (version 83.38)

Entrez gene

 81890

UniProt

 Q9BXR0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXR0

Antibodypedia

 QTRT1 antibodies

PROTEIN BROWSER
QTRT1-001
QTRT1-007
QTRT1-009
QTRT1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
QTRT1-001
ENSP00000250237
ENST00000250237
Q9BXR0 [Direct mapping]
Queuine tRNA-ribosyltransferase
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Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0006400 [tRNA modification]
GO:0008033 [tRNA processing]
GO:0008479 [queuine tRNA-ribosyltransferase activity]
GO:0008616 [queuosine biosynthetic process]
GO:0010467 [gene expression]
GO:0046872 [metal ion binding]
Show all
 403 aa
44 kDa 		No 0
QTRT1-007
ENSP00000468811
ENST00000592254
K7ESP6 [Direct mapping]
Queuine tRNA-ribosyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006400 [tRNA modification]
GO:0008479 [queuine tRNA-ribosyltransferase activity]
GO:0008616 [queuosine biosynthetic process]
Show all
 180 aa
19.8 kDa 		No 0
QTRT1-009
ENSP00000467394
ENST00000591643
K7EPI1 [Direct mapping]
Queuine tRNA-ribosyltransferase
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006400 [tRNA modification]
GO:0008479 [queuine tRNA-ribosyltransferase activity]
GO:0008616 [queuosine biosynthetic process]
Show all
 124 aa
13.4 kDa 		No 0
QTRT1-011
ENSP00000465974
ENST00000592376
K7EL95 [Direct mapping]
Queuine tRNA-ribosyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006400 [tRNA modification]
GO:0008479 [queuine tRNA-ribosyltransferase activity]
GO:0008616 [queuosine biosynthetic process]
Show all
 136 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.