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Most of the cancer tissues showed weak to moderate cytoplasmic positivity with additional membranous positivity in some cases. Most renal cancers and occasional hepatocellular carcinomas were strongly stained with additional nuclear positivity in renal cancers. Several lymphomas, cervical, lung, and testicular cancers along with squamous and basal cell carcinomas were negative.
GENE INFORMATION
Gene name
COG8 (HGNC Symbol)
Synonyms
DOR1, FLJ22315
Description
Component of oligomeric golgi complex 8 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]
THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
