Cell atlas - COG8 - The Human Protein Atlas

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COG8

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	COG8
Gene description	Component of oligomeric golgi complex 8
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA049429
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049429	A-431	Golgi apparatus	Intensity
	HPA049429	MCF7	Golgi apparatus
	HPA049429	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	COG8 (HGNC Symbol)
Synonyms	DOR1, FLJ22315
Description	Component of oligomeric golgi complex 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	69320140 - 69339667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213380 (version 83.38)
Entrez gene	84342
UniProt	Q96MW5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MW5
Antibodypedia	COG8 antibodies

PROTEIN BROWSER

COG8-001	COG8-002	COG8-003	COG8-006	COG8-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COG8-001 ENSP00000305459 ENST00000306875	Q96MW5 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 A0A024R6Z6 [Target identity:100%; Query identity:100%] HCG2027080, isoform CRA_b Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017119 [Golgi transport complex] Show all	612 aa 68.4 kDa	No	0
COG8-002 ENSP00000464395 ENST00000567493	J3QRV3 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	99 aa 11.7 kDa	No	0
COG8-003 ENSP00000455954 ENST00000562081	H3BQV3 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	534 aa 60.4 kDa	No	0
COG8-006 ENSP00000456705 ENST00000562595	H3BSH5 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	223 aa 25.6 kDa	No	0
COG8-007 ENSP00000484442 ENST00000615447	A0A087X1T3 [Direct mapping] Conserved oligomeric Golgi complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0017119 [Golgi transport complex] Show all	121 aa 13.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.