Expression of TREX1 in cancer - Summary

CANCER ATLAS

Gene description

Three prime repair exonuclease 1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035437

GENE INFORMATION
Gene name	TREX1 (HGNC Symbol)
Synonyms	AGS1, DRN3
Description	Three prime repair exonuclease 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48465811 - 48467645
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213689 (version 83.38)
Entrez gene	11277
UniProt	Q9NSU2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NSU2
Antibodypedia	TREX1 antibodies

PROTEIN BROWSER

TREX1-003	TREX1-004	TREX1-005	TREX1-007	TREX1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TREX1-003 ENSP00000412404 ENST00000433541	C9J052 [Direct mapping] Three-prime repair exonuclease 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0016021 [integral component of membrane] Show all	175 aa 18.4 kDa	No	1
TREX1-004 ENSP00000415972 ENST00000444177	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	304 aa 32.3 kDa	No	1
TREX1-005 ENSP00000411331 ENST00000456089	C9J052 [Direct mapping] Three-prime repair exonuclease 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0016021 [integral component of membrane] Show all	175 aa 18.4 kDa	No	1
TREX1-007 ENSP00000486676 ENST00000625293	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	369 aa 38.9 kDa	No	1
TREX1-008 ENSP00000486444 ENST00000629913	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	314 aa 33.2 kDa	No	1