Tissue expression of TREX1 - Summary - The Human Protein Atlas

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TREX1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TREX1
Gene description	Three prime repair exonuclease 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA035437
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TREX1 (HGNC Symbol)
Synonyms	AGS1, DRN3
Description	Three prime repair exonuclease 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48465811 - 48467645
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213689 (version 83.38)
Entrez gene	11277
UniProt	Q9NSU2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NSU2
Antibodypedia	TREX1 antibodies

PROTEIN BROWSER

TREX1-003	TREX1-004	TREX1-005	TREX1-007	TREX1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TREX1-003 ENSP00000412404 ENST00000433541	C9J052 [Direct mapping] Three-prime repair exonuclease 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0016021 [integral component of membrane] Show all	175 aa 18.4 kDa	No	1
TREX1-004 ENSP00000415972 ENST00000444177	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	304 aa 32.3 kDa	No	1
TREX1-005 ENSP00000411331 ENST00000456089	C9J052 [Direct mapping] Three-prime repair exonuclease 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0016021 [integral component of membrane] Show all	175 aa 18.4 kDa	No	1
TREX1-007 ENSP00000486676 ENST00000625293	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	369 aa 38.9 kDa	No	1
TREX1-008 ENSP00000486444 ENST00000629913	Q9NSU2 [Direct mapping] Three-prime repair exonuclease 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000738 [DNA catabolic process, exonucleolytic] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005730 [nucleolus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006259 [DNA metabolic process] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006298 [mismatch repair] GO:0006310 [DNA recombination] GO:0008296 [3'-5'-exodeoxyribonuclease activity] GO:0008408 [3'-5' exonuclease activity] GO:0008853 [exodeoxyribonuclease III activity] GO:0032405 [MutLalpha complex binding] GO:0032407 [MutSalpha complex binding] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] Show all	314 aa 33.2 kDa	No	1

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The Human Protein Atlas

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