Expression of MEF2B in cancer - Summary

CANCER ATLAS

Gene description

Myocyte enhancer factor 2B

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004734

GENE INFORMATION
Gene name	MEF2B (HGNC Symbol)
Synonyms	RSRFR2
Description	Myocyte enhancer factor 2B (HGNC Symbol)
Entrez gene summary	The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	19145568 - 19170289
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000213999 (version 83.38)
Entrez gene	100271849
UniProt	Q02080 (UniProt - Evidence at protein level)
neXtProt	NX_Q02080
Antibodypedia	MEF2B antibodies

PROTEIN BROWSER

MEF2B-001	MEF2B-004	MEF2B-005	MEF2B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEF2B-001 ENSP00000402154 ENST00000424583	Q02080 [Direct mapping] Myocyte-specific enhancer factor 2B A0A024R7K5 [Target identity:100%; Query identity:100%] MADS box transcription enhancer factor 2, polypeptide B (Myocyte enhancer factor 2B), isoform CRA_a Show all	Predicted intracellular proteins Transcription factors alpha-Helices exposed by beta-structures Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007517 [muscle organ development] GO:0030054 [cell junction] GO:0042826 [histone deacetylase binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	368 aa 39.1 kDa	No	0
MEF2B-004 ENSP00000386480 ENST00000409224	B3KQ23 [Direct mapping] Myocyte-specific enhancer factor 2B; cDNA FLJ32648 fis, clone SYNOV2001451, highly similar to MYOCYTE-SPECIFIC ENHANCER FACTOR 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030054 [cell junction] GO:0046983 [protein dimerization activity] Show all	297 aa 31.8 kDa	No	0
MEF2B-005 ENSP00000386374 ENST00000410050	C9J4J4 [Direct mapping] Myocyte-specific enhancer factor 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030054 [cell junction] GO:0046983 [protein dimerization activity] Show all	375 aa 39.8 kDa	No	0
MEF2B-006 ENSP00000386784 ENST00000409447	B8ZZJ5 [Direct mapping] Myocyte-specific enhancer factor 2B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030054 [cell junction] GO:0046983 [protein dimerization activity] Show all	286 aa 31.2 kDa	No	0