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MEF2B

GENERAL INFORMATION

Gene name

 MEF2B

Gene description

 Myocyte enhancer factor 2B

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lymph node, tonsil, appendix)
GTEx:Mixed
FANTOM5:Group enriched (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective nuclear expression in germinal center lymphocytes of tonsil and lymph node.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA004734
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lymph node, tonsil, appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, tonsil)

GENE INFORMATION

Gene name

 MEF2B (HGNC Symbol)

Synonyms

 RSRFR2

Description

 Myocyte enhancer factor 2B (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 19145568 - 19170289

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000213999 (version 83.38)

Entrez gene

 100271849

UniProt

 Q02080 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02080

Antibodypedia

 MEF2B antibodies

PROTEIN BROWSER
MEF2B-001
MEF2B-004
MEF2B-005
MEF2B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEF2B-001
ENSP00000402154
ENST00000424583
Q02080 [Direct mapping]
Myocyte-specific enhancer factor 2B
A0A024R7K5 [Target identity:100%; Query identity:100%]
MADS box transcription enhancer factor 2, polypeptide B (Myocyte enhancer factor 2B), isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007517 [muscle organ development]
GO:0030054 [cell junction]
GO:0042826 [histone deacetylase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
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 368 aa
39.1 kDa 		No 0
MEF2B-004
ENSP00000386480
ENST00000409224
B3KQ23 [Direct mapping]
Myocyte-specific enhancer factor 2B; cDNA FLJ32648 fis, clone SYNOV2001451, highly similar to MYOCYTE-SPECIFIC ENHANCER FACTOR 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030054 [cell junction]
GO:0046983 [protein dimerization activity]
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 297 aa
31.8 kDa 		No 0
MEF2B-005
ENSP00000386374
ENST00000410050
C9J4J4 [Direct mapping]
Myocyte-specific enhancer factor 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030054 [cell junction]
GO:0046983 [protein dimerization activity]
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 375 aa
39.8 kDa 		No 0
MEF2B-006
ENSP00000386784
ENST00000409447
B8ZZJ5 [Direct mapping]
Myocyte-specific enhancer factor 2B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030054 [cell junction]
GO:0046983 [protein dimerization activity]
Show all
 286 aa
31.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.