Expression of GANC in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glucosidase, alpha; neutral C

Protein class

Enzymes, FDA approved drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA016949

GENE INFORMATION
Gene name	GANC
Synonyms
Description	Glucosidase, alpha; neutral C (HGNC Symbol)
Entrez gene summary	Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	42273233 - 42356935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214013 (version 83.38)
Entrez gene	2595
UniProt	Q8TET4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TET4
Antibodypedia	GANC antibodies

PROTEIN BROWSER

GANC-001	GANC-002	GANC-003	GANC-005	GANC-008	GANC-009	GANC-012	GANC-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GANC-001 ENSP00000326227 ENST00000318010	Q8TET4 [Direct mapping] Neutral alpha-glucosidase C Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000023 [maltose metabolic process] GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004558 [alpha-1,4-glucosidase activity] GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] GO:0032450 [maltose alpha-glucosidase activity] Show all	914 aa 104.3 kDa	No	0
GANC-002 ENSP00000454747 ENST00000566442	H3BN99 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] Show all	357 aa 40.3 kDa	No	0
GANC-003 ENSP00000399557 ENST00000440615	E7EWB6 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		282 aa 31.6 kDa	No	0
GANC-005 ENSP00000454578 ENST00000562170	H3BMW3 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.9 kDa	No	0
GANC-008 ENSP00000454816 ENST00000561871	A0A0G2JLA2 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1 kDa	No	0
GANC-009 ENSP00000454449 ENST00000562859	H3BMM3 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.8 kDa	No	0
GANC-012 ENSP00000457604 ENST00000567596	H3BUE8 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.6 kDa	No	0
GANC-013 ENSP00000455511 ENST00000566690	H3BPX5 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.5 kDa	No	0