Cell atlas - GANC - The Human Protein Atlas

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GANC

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Nucleoplasm

Human cell
	Actin Filaments
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GANC
Gene description	Glucosidase, alpha; neutral C
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the actin filaments & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Actin filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016949
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the actin filaments & nucleoplasm.

Main location

Nucleoplasm (approved), Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016949	A-431	Nucleoplasm
	HPA016949	A-431	Actin filaments
	HPA016949	U-2 OS	Nucleoplasm
	HPA016949	U-2 OS	Actin filaments
	HPA016949	U-251 MG	Nucleoplasm
	HPA016949	U-251 MG	Actin filaments

GENE INFORMATION
Gene name	GANC
Synonyms
Description	Glucosidase, alpha; neutral C (HGNC Symbol)
Entrez gene summary	Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	42273233 - 42356935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214013 (version 83.38)
Entrez gene	2595
UniProt	Q8TET4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TET4
Antibodypedia	GANC antibodies

PROTEIN BROWSER

GANC-001	GANC-002	GANC-003	GANC-005	GANC-008	GANC-009	GANC-012	GANC-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GANC-001 ENSP00000326227 ENST00000318010	Q8TET4 [Direct mapping] Neutral alpha-glucosidase C Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000023 [maltose metabolic process] GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004558 [alpha-1,4-glucosidase activity] GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] GO:0032450 [maltose alpha-glucosidase activity] Show all	914 aa 104.3 kDa	No	0
GANC-002 ENSP00000454747 ENST00000566442	H3BN99 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0030246 [carbohydrate binding] Show all	357 aa 40.3 kDa	No	0
GANC-003 ENSP00000399557 ENST00000440615	E7EWB6 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		282 aa 31.6 kDa	No	0
GANC-005 ENSP00000454578 ENST00000562170	H3BMW3 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.9 kDa	No	0
GANC-008 ENSP00000454816 ENST00000561871	A0A0G2JLA2 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1 kDa	No	0
GANC-009 ENSP00000454449 ENST00000562859	H3BMM3 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.8 kDa	No	0
GANC-012 ENSP00000457604 ENST00000567596	H3BUE8 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.6 kDa	No	0
GANC-013 ENSP00000455511 ENST00000566690	H3BPX5 [Direct mapping] Neutral alpha-glucosidase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.