Cell atlas - HAUS3 - The Human Protein Atlas

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HAUS3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Mitochondria

Human cell
	Microtubules
	Mitochondria

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GENERAL INFORMATION
Gene name	HAUS3
Gene description	HAUS augmin-like complex, subunit 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria & microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (supported), Mitochondria (uncertain)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040649
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria & microtubules.

Main location

Microtubules (supported), Mitochondria (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040649	PC-3	Nucleoplasm
	HPA040649	PC-3	Microtubules
	HPA040649	RH-30	Microtubules
	HPA040649	RH-30	Mitochondria
	HPA040649	U-2 OS	Microtubules
	HPA040649	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	HAUS3 (HGNC Symbol)
Synonyms	C4orf15, dgt3, IT1, MGC4701
Description	HAUS augmin-like complex, subunit 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2227464 - 2242164
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214367 (version 83.38)
Entrez gene	79441
UniProt	Q68CZ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q68CZ6
Antibodypedia	HAUS3 antibodies

PROTEIN BROWSER

HAUS3-001	HAUS3-002	HAUS3-003	HAUS3-004	HAUS3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAUS3-001 ENSP00000243706 ENST00000243706	Q68CZ6 [Direct mapping] HAUS augmin-like complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0007067 [mitotic nuclear division] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	603 aa 69.6 kDa	No	0
HAUS3-002 ENSP00000392903 ENST00000443786	Q68CZ6 [Direct mapping] HAUS augmin-like complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0007067 [mitotic nuclear division] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	603 aa 69.6 kDa	No	0
HAUS3-003 ENSP00000427350 ENST00000506763	Q68CZ6 [Direct mapping] HAUS augmin-like complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0007067 [mitotic nuclear division] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	489 aa 56.4 kDa	No	0
HAUS3-004 ENSP00000427356 ENST00000502440		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.1 kDa	No	0
HAUS3-005 ENSP00000423285 ENST00000514395	D6R993 [Direct mapping] HAUS augmin-like complex subunit 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051225 [spindle assembly] GO:0070652 [HAUS complex] Show all	33 aa 3.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.