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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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HBD
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HBD

Gene description

Hemoglobin, delta

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (bone marrow)
GTEx:Tissue enriched (spleen)
FANTOM5:Tissue enhanced (lung, placenta, vagina)

Protein evidence

Evidence at protein level

Protein expression

Expression in erythrocytes.

DATA RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images. Tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 2 antibodies.
HPA043234 , CAB037087
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung, placenta, vagina)

GENE INFORMATION

Gene name

HBD

Synonyms

Description

Hemoglobin, delta (HGNC Symbol)

Entrez gene summary

The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

5232678 - 5235370

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000223609 (version 83.38)

Entrez gene

3045

UniProt

P02042 (UniProt - Evidence at protein level)

neXtProt

NX_P02042

Antibodypedia

HBD antibodies

PROTEIN BROWSER

HBD-001
HBD-002
HBD-003
HBD-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HBD-001
ENSP00000369654
ENST00000380299
P02042 [Direct mapping]
Hemoglobin subunit delta
A0N071 [Target identity:100%; Query identity:100%]
Delta globin; Delta-globin chain; Hemoglobin delta; Hemoglobin, delta
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005833 [hemoglobin complex]
GO:0007596 [blood coagulation]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0072562 [blood microparticle]
Show all
147 aa
16.1 kDa
No 0
HBD-002
ENSP00000414741
ENST00000417377
C9JRG0 [Direct mapping]
Hemoglobin subunit delta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0015671 [oxygen transport]
GO:0016021 [integral component of membrane]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
85 aa
9.8 kDa
No 1
HBD-003
ENSP00000292901
ENST00000292901
E9PFT6 [Direct mapping]
Hemoglobin subunit delta
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
141 aa
15.4 kDa
No 0
HBD-004
ENSP00000393810
ENST00000429817
E9PEW8 [Direct mapping]
Hemoglobin subunit delta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
104 aa
11.3 kDa
No 0

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