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Most of the malignant cells displayed weak to moderate membranous and/or cytoplasmic staining with additional nuclear immunoreactivity in some cases. A few non-Hodgkins lymphomas, colorectal, ovarian and urothelial cancers were strongly stained. Many malignant gliomas, breast, prostate, endometrial and renal cancers were negative.
GENE INFORMATION
Gene name
SPANXB1 (HGNC Symbol)
Synonyms
CT11.2, SPANXB2, SPANXF1, SPANXF2
Description
SPANX family, member B1 (HGNC Symbol)
Entrez gene summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014]
Q9NS25 [Target identity:100%; Query identity:100%] Sperm protein associated with the nucleus on the X chromosome B1 A0A0G2JJ56 [Direct mapping] Sperm protein-associated with the nucleus on the X chromosome B1
