Cell atlas - SPANXB1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SPANXB1
Gene description	SPANX family, member B1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Group enriched (A-431, U-2 OS)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046423
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (A-431, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA046423	A-431	Nucleoplasm
HPA046423	A549	Nucleoplasm
HPA046423	U-2 OS	Nucleoplasm
HPA046423	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SPANXB1 (HGNC Symbol)
Synonyms	CT11.2, SPANXB2, SPANXF1, SPANXF2
Description	SPANX family, member B1 (HGNC Symbol)
Entrez gene summary	Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014]
Chromosome	X
Cytoband	q27.1
Chromosome location (bp)	141002591 - 141003706
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000227234 (version 83.38)
Entrez gene	728695
UniProt	Q9NS25 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NS25
Antibodypedia	SPANXB1 antibodies

PROTEIN BROWSER

SPANXB1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPANXB1-001 ENSP00000405202 ENST00000449283	Q9NS25 [Target identity:100%; Query identity:100%] Sperm protein associated with the nucleus on the X chromosome B1 A0A0G2JJ56 [Direct mapping] Sperm protein-associated with the nucleus on the X chromosome B1 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007286 [spermatid development] Show all	103 aa 11.8 kDa	No	0