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LTB

GENERAL INFORMATION

Gene name

 LTB

Gene description

 Lymphotoxin beta (TNF superfamily, member 3)

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (spleen, lymph node, appendix, tonsil)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Group enriched (tonsil, appendix, spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA048884
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, lymph node, appendix, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, appendix, spleen, lymph node)

GENE INFORMATION

Gene name

 LTB (HGNC Symbol)

Synonyms

 p33, TNFC, TNFSF3

Description

 Lymphotoxin beta (TNF superfamily, member 3) (HGNC Symbol)

Entrez gene summary

 Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31580525 - 31582522

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000227507 (version 83.38)

Entrez gene

 4050

UniProt

 Q06643 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06643

Antibodypedia

 LTB antibodies

PROTEIN BROWSER
LTB-001
LTB-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LTB-001
ENSP00000410481
ENST00000429299
Q06643 [Direct mapping]
Lymphotoxin-beta
Q5STB2 [Target identity:100%; Query identity:100%]
LTB protein; Lymphotoxin beta; Lymphotoxin beta (TNF superfamily, member 3); Lymphotoxin beta (TNF superfamily, member 3), isoform CRA_b
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0043588 [skin development]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
GO:0048535 [lymph node development]
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 244 aa
25.4 kDa 		No 0
LTB-002
ENSP00000416113
ENST00000446745
Q06643 [Direct mapping]
Lymphotoxin-beta
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
Show all
 77 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.