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TXNDC5

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GENERAL INFORMATION

Gene name

 TXNDC5

Gene description

 Thioredoxin domain containing 5 (endoplasmic reticulum)

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the endoplasmic reticulum.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA034678
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the endoplasmic reticulum.

Main location

 Endoplasmic reticulum (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA034678 A-431 Endoplasmic reticulum
HPA034678 U-2 OS Endoplasmic reticulum
HPA034678 U-251 MG Endoplasmic reticulum

GENE INFORMATION

Gene name

 TXNDC5 (HGNC Symbol)

Synonyms

 EndoPDI, ERp46, FLJ21353, FLJ90810, Hcc-2, MGC3178, PDIA15

Description

 Thioredoxin domain containing 5 (endoplasmic reticulum) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]

Chromosome

 6

Cytoband

 p24.3

Chromosome location (bp)

 7881517 - 7910814

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239264 (version 83.38)

Entrez gene

 81567

UniProt

 Q8NBS9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NBS9

Antibodypedia

 TXNDC5 antibodies

PROTEIN BROWSER
TXNDC5-001
TXNDC5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNDC5-001
ENSP00000369081
ENST00000379757
Q8NBS9 [Direct mapping]
Thioredoxin domain-containing protein 5
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008152 [metabolic process]
GO:0016853 [isomerase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043277 [apoptotic cell clearance]
GO:0045454 [cell redox homeostasis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 432 aa
47.6 kDa 		Yes 0
TXNDC5-003
ENSP00000420784
ENST00000473453
Q8NBS9 [Direct mapping]
Thioredoxin domain-containing protein 5
A0A024QZV0 [Target identity:100%; Query identity:100%]
HCG1811539, isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003756 [protein disulfide isomerase activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006457 [protein folding]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008152 [metabolic process]
GO:0016853 [isomerase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043066 [negative regulation of apoptotic process]
GO:0043202 [lysosomal lumen]
GO:0043277 [apoptotic cell clearance]
GO:0045454 [cell redox homeostasis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 324 aa
36.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.