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Cases of renal, colorectal, gastric and liver cancers showed moderate to strong membraneous positivity. Remaining malignancies were negative.
GENE INFORMATION
Gene name
AQP1 (HGNC Symbol)
Synonyms
CHIP28, CO
Description
Aquaporin 1 (Colton blood group) (HGNC Symbol)
Entrez gene summary
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]