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AQP1

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GENERAL INFORMATION

Gene name

 AQP1

Gene description

 Aquaporin 1 (Colton blood group)

Protein class

 Blood group antigen proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enhanced (WM-115, EFO-21, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA019206
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, EFO-21, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019206 HeLa Plasma membrane
HPA019206 RH-30 Plasma membrane
HPA019206 U-2 OS Plasma membrane

GENE INFORMATION

Gene name

 AQP1 (HGNC Symbol)

Synonyms

 CHIP28, CO

Description

 Aquaporin 1 (Colton blood group) (HGNC Symbol)

Entrez gene summary

 Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 7

Cytoband

 p14.3

Chromosome location (bp)

 30911855 - 30925516

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000240583 (version 83.38)

Entrez gene

 358

UniProt

 P29972 (UniProt - Evidence at protein level)

neXtProt

 NX_P29972

Antibodypedia

 AQP1 antibodies

PROTEIN BROWSER
AQP1-001
AQP1-002
AQP1-003
AQP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP1-001
ENSP00000311165
ENST00000311813
P29972 [Direct mapping]
Aquaporin-1
A0A024RA31 [Target identity:100%; Query identity:100%]
Aquaporin 1 (Channel-forming integral protein, 28kDa); HCG39137, isoform CRA_a
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003094 [glomerular filtration]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0006972 [hyperosmotic response]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009725 [response to hormone]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019233 [sensory perception of pain]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030104 [water homeostasis]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0032809 [neuronal cell body membrane]
GO:0032940 [secretion by cell]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033363 [secretory granule organization]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042060 [wound healing]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042538 [hyperosmotic salinity response]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043627 [response to estrogen]
GO:0043679 [axon terminus]
GO:0044241 [lipid digestion]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046875 [ephrin receptor binding]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048593 [camera-type eye morphogenesis]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051458 [corticotropin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070295 [renal water absorption]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072220 [metanephric descending thin limb development]
GO:0072230 [metanephric proximal straight tubule development]
GO:0072232 [metanephric proximal convoluted tubule segment 2 development]
GO:0072239 [metanephric glomerulus vasculature development]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 269 aa
28.5 kDa 		No 6
AQP1-002
ENSP00000387178
ENST00000409611
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 218 aa
23.4 kDa 		No 3
AQP1-003
ENSP00000386712
ENST00000409899
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 154 aa
16.7 kDa 		No 3
AQP1-201
ENSP00000405698
ENST00000441328
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 186 aa
20 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.