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ARPC4

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GENERAL INFORMATION

Gene name

 ARPC4

Gene description

 Actin related protein 2/3 complex, subunit 4, 20kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ARPC4 (HGNC Symbol)

Synonyms

 ARC20, p20-Arc

Description

 Actin related protein 2/3 complex, subunit 4, 20kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 9792495 - 9807726

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000241553 (version 83.38)

Entrez gene

 10093

UniProt

 P59998 (UniProt - Evidence at protein level)

neXtProt

 NX_P59998

Antibodypedia

 ARPC4 antibodies

PROTEIN BROWSER
ARPC4-001
ARPC4-005
ARPC4-009
ARPC4-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC4-001
ENSP00000380431
ENST00000397261
P59998 [Direct mapping]
Actin-related protein 2/3 complex subunit 4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0030041 [actin filament polymerization]
GO:0030674 [protein binding, bridging]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0045010 [actin nucleation]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 168 aa
19.7 kDa 		No 0
ARPC4-005
ENSP00000432235
ENST00000498623
P59998 [Direct mapping]
Actin-related protein 2/3 complex subunit 4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0030041 [actin filament polymerization]
GO:0030674 [protein binding, bridging]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0045010 [actin nucleation]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 78 aa
9.6 kDa 		No 0
ARPC4-009
ENSP00000473435
ENST00000485273
R4GN08 [Direct mapping]
Actin-related protein 2/3 complex subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005885 [Arp2/3 protein complex]
GO:0015629 [actin cytoskeleton]
GO:0030041 [actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
Show all
 77 aa
9.4 kDa 		No 0
ARPC4-010
ENSP00000388169
ENST00000433034
P59998 [Direct mapping]
Actin-related protein 2/3 complex subunit 4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0030041 [actin filament polymerization]
GO:0030674 [protein binding, bridging]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0045010 [actin nucleation]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 187 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.