Tissue expression of ARPC4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ARPC4
Gene description	Actin related protein 2/3 complex, subunit 4, 20kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ARPC4 (HGNC Symbol)
Synonyms	ARC20, p20-Arc
Description	Actin related protein 2/3 complex, subunit 4, 20kDa (HGNC Symbol)
Entrez gene summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9792495 - 9807726
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241553 (version 83.38)
Entrez gene	10093
UniProt	P59998 (UniProt - Evidence at protein level)
neXtProt	NX_P59998
Antibodypedia	ARPC4 antibodies

PROTEIN BROWSER

ARPC4-001	ARPC4-005	ARPC4-009	ARPC4-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARPC4-001 ENSP00000380431 ENST00000397261	P59998 [Direct mapping] Actin-related protein 2/3 complex subunit 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0015629 [actin cytoskeleton] GO:0019899 [enzyme binding] GO:0030041 [actin filament polymerization] GO:0030674 [protein binding, bridging] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995 [cell projection] GO:0045010 [actin nucleation] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	168 aa 19.7 kDa	No	0
ARPC4-005 ENSP00000432235 ENST00000498623	P59998 [Direct mapping] Actin-related protein 2/3 complex subunit 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0015629 [actin cytoskeleton] GO:0019899 [enzyme binding] GO:0030041 [actin filament polymerization] GO:0030674 [protein binding, bridging] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995 [cell projection] GO:0045010 [actin nucleation] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	78 aa 9.6 kDa	No	0
ARPC4-009 ENSP00000473435 ENST00000485273	R4GN08 [Direct mapping] Actin-related protein 2/3 complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005885 [Arp2/3 protein complex] GO:0015629 [actin cytoskeleton] GO:0030041 [actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] Show all	77 aa 9.4 kDa	No	0
ARPC4-010 ENSP00000388169 ENST00000433034	P59998 [Direct mapping] Actin-related protein 2/3 complex subunit 4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0015629 [actin cytoskeleton] GO:0019899 [enzyme binding] GO:0030041 [actin filament polymerization] GO:0030674 [protein binding, bridging] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042995 [cell projection] GO:0045010 [actin nucleation] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	187 aa 21.6 kDa	No	0