Expression of ATP5O in cancer - Summary

CANCER ATLAS

Gene description

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041394	CAB016209

GENE INFORMATION
Gene name	ATP5O (HGNC Symbol)
Synonyms	ATPO, OSCP
Description	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	33903453 - 33915980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241837 (version 83.38)
Entrez gene	539
UniProt	P48047 (UniProt - Evidence at protein level)
neXtProt	NX_P48047
Antibodypedia	ATP5O antibodies

PROTEIN BROWSER

ATP5O-001	ATP5O-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5O-001 ENSP00000290299 ENST00000290299	P48047 [Direct mapping] ATP synthase subunit O, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0005886 [plasma membrane] GO:0006754 [ATP biosynthetic process] GO:0008144 [drug binding] GO:0015986 [ATP synthesis coupled proton transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0070062 [extracellular exosome] Show all	213 aa 23.3 kDa	No	0
ATP5O-010 ENSP00000393211 ENST00000418933	H7C068 [Direct mapping] ATP synthase subunit O, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015986 [ATP synthesis coupled proton transport] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] Show all	86 aa 9.4 kDa	No	0