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ATP5O

GENERAL INFORMATION

Gene name

 ATP5O

Gene description

 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041394 , CAB016209
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATP5O (HGNC Symbol)

Synonyms

 ATPO, OSCP

Description

 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 33903453 - 33915980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000241837 (version 83.38)

Entrez gene

 539

UniProt

 P48047 (UniProt - Evidence at protein level)

neXtProt

 NX_P48047

Antibodypedia

 ATP5O antibodies

PROTEIN BROWSER
ATP5O-001
ATP5O-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5O-001
ENSP00000290299
ENST00000290299
P48047 [Direct mapping]
ATP synthase subunit O, mitochondrial
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005886 [plasma membrane]
GO:0006754 [ATP biosynthetic process]
GO:0008144 [drug binding]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0070062 [extracellular exosome]
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 213 aa
23.3 kDa 		No 0
ATP5O-010
ENSP00000393211
ENST00000418933
H7C068 [Direct mapping]
ATP synthase subunit O, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0015986 [ATP synthesis coupled proton transport]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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 86 aa
9.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.