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Lymphomas displayed moderate to strong cytoplasmic immunoreactivity. Moderate staining was observed in most cases of hepatocellular carcinomas, breast and renal cancers along with several melanomas, testicular and endometrial cancers. Remaining Cancer tissues were generally negative.
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]