Cell atlas - PI4KA - The Human Protein Atlas

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PI4KA

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PI4KA
Gene description	Phosphatidylinositol 4-kinase, catalytic, alpha
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA075515
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075515	MCF7	Nucleoplasm
	HPA075515	MCF7	Plasma membrane
	HPA075515	RH-30	Nucleoplasm
	HPA075515	RH-30	Plasma membrane
	HPA075515	U-2 OS	Nucleoplasm
			Plasma membrane
			Cell Junctions

GENE INFORMATION
Gene name	PI4KA (HGNC Symbol)
Synonyms	PI4K-ALPHA, pi4K230, PIK4CA
Description	Phosphatidylinositol 4-kinase, catalytic, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	20707691 - 20859417
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241973 (version 83.38)
Entrez gene	5297
UniProt
neXtProt
Antibodypedia	PI4KA antibodies

PROTEIN BROWSER

PI4KA-001	PI4KA-006	PI4KA-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PI4KA-001 ENSP00000255882 ENST00000255882	J3KN10 [Direct mapping] Phosphatidylinositol 4-kinase alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004430 [1-phosphatidylinositol 4-kinase activity] GO:0005488 [binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] Show all	2102 aa 236.8 kDa	No	2
PI4KA-006 ENSP00000382162 ENST00000399213	A8MTF1 [Direct mapping] Phosphatidylinositol 4-kinase alpha Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004430 [1-phosphatidylinositol 4-kinase activity] GO:0005488 [binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] Show all	435 aa 49.6 kDa	No	0
PI4KA-007 ENSP00000402437 ENST00000449120	C9JLI1 [Direct mapping] Phosphatidylinositol 4-kinase alpha Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004430 [1-phosphatidylinositol 4-kinase activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0046854 [phosphatidylinositol phosphorylation] GO:0048015 [phosphatidylinositol-mediated signaling] Show all	87 aa 9.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.