Tissue expression of SERPINB10 - Summary - The Human Protein Atlas

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SERPINB10

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SERPINB10
Gene description	Serpin peptidase inhibitor, clade B (ovalbumin), member 10
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (bone marrow)
GTEx:	Not detected
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in a subset of inflammatory cells.

DATA RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 2 antibodies. HPA015480 , HPA059582
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	SERPINB10 (HGNC Symbol)
Synonyms	bomapin, PI10
Description	Serpin peptidase inhibitor, clade B (ovalbumin), member 10 (HGNC Symbol)
Entrez gene summary	This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
Chromosome	18
Cytoband
Chromosome location (bp)	63897174 - 63936111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000242550 (version 83.38)
Entrez gene	5273
UniProt	P48595 (UniProt - Evidence at protein level)
neXtProt	NX_P48595
Antibodypedia	SERPINB10 antibodies

PROTEIN BROWSER

SERPINB10-001	SERPINB10-002	SERPINB10-003	SERPINB10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINB10-001 ENSP00000238508 ENST00000238508	P48595 [Direct mapping] Serpin B10 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	397 aa 45.4 kDa	No	0
SERPINB10-002 ENSP00000381082 ENST00000397996	H7BYS2 [Direct mapping] Serpin B10 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0043066 [negative regulation of apoptotic process] Show all	280 aa 31.4 kDa	No	0
SERPINB10-003 ENSP00000392381 ENST00000418725	H7C004 [Direct mapping] Serpin B10 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0043066 [negative regulation of apoptotic process] Show all	253 aa 28.5 kDa	No	0
SERPINB10-201 ENSP00000479385 ENST00000619595	P48595 [Direct mapping] Serpin B10 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0010951 [negative regulation of endopeptidase activity] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	397 aa 45.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.