Cell atlas - TNFRSF6B - The Human Protein Atlas

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TNFRSF6B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TNFRSF6B
Gene description	Tumor necrosis factor receptor superfamily, member 6b, decoy
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (RPTEC TERT1, TIME, PC-3)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1, TIME, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TNFRSF6B (HGNC Symbol)
Synonyms	DcR3, M68, TR6
Description	Tumor necrosis factor receptor superfamily, member 6b, decoy (HGNC Symbol)
Entrez gene summary	This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	63696668 - 63698684
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243509 (version 83.38)
Entrez gene	8771
UniProt	O95407 (UniProt - Evidence at protein level)
neXtProt	NX_O95407
Antibodypedia	TNFRSF6B antibodies

PROTEIN BROWSER

TNFRSF6B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFRSF6B-001 ENSP00000359013 ENST00000369996	O95407 [Direct mapping] Tumor necrosis factor receptor superfamily member 6B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007275 [multicellular organismal development] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0043066 [negative regulation of apoptotic process] GO:0043410 [positive regulation of MAPK cascade] GO:0097190 [apoptotic signaling pathway] Show all	300 aa 32.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.