Fields »
ABOUT
HELP
BLOG
TNFRSF6B

GENERAL INFORMATION

Gene name

 TNFRSF6B

Gene description

 Tumor necrosis factor receptor superfamily, member 6b, decoy

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (appendix)
FANTOM5:Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastrointestinal tract and CNS.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA047154
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (appendix)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)

GENE INFORMATION

Gene name

 TNFRSF6B (HGNC Symbol)

Synonyms

 DcR3, M68, TR6

Description

 Tumor necrosis factor receptor superfamily, member 6b, decoy (HGNC Symbol)

Entrez gene summary

 This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63696668 - 63698684

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243509 (version 83.38)

Entrez gene

 8771

UniProt

 O95407 (UniProt - Evidence at protein level)

neXtProt

 NX_O95407

Antibodypedia

 TNFRSF6B antibodies

PROTEIN BROWSER
TNFRSF6B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF6B-001
ENSP00000359013
ENST00000369996
O95407 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6B
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0097190 [apoptotic signaling pathway]
Show all
 300 aa
32.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.