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Tumors generally showed moderate to strong nuclear positivity. Strongest immunoreactivity was observed in malignant lymphomas, colorectal cancers and urothelial cancers. A few liver cancer were weakly stained.
GENE INFORMATION
Gene name
CDK11B (HGNC Symbol)
Synonyms
CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58
Description
Cyclin-dependent kinase 11B (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]