Cell atlas - CDK11B - The Human Protein Atlas

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CDK11B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDK11B
Gene description	Cyclin-dependent kinase 11B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA073626
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA073626	SK-MEL-30	Nuclear speckles
	HPA073626	SiHa	Nuclear speckles
	HPA073626	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	CDK11B (HGNC Symbol)
Synonyms	CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58
Description	Cyclin-dependent kinase 11B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1635227 - 1659012
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000248333 (version 83.38)
Entrez gene	984
UniProt
neXtProt
Antibodypedia	CDK11B antibodies

PROTEIN BROWSER

CDK11B-001	CDK11B-003	CDK11B-005	CDK11B-201	CDK11B-202	CDK11B-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK11B-001 ENSP00000463048 ENST00000341832	B7ZVY7 [Direct mapping] Cell division cycle 2-like 1 (PITSLRE proteins); Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0051301 [cell division] Show all	782 aa 91.3 kDa	No	0
CDK11B-003 ENSP00000464036 ENST00000407249	J3QR44 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	795 aa 92.6 kDa	No	0
CDK11B-005 ENSP00000464016 ENST00000340677	J3QR29 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	748 aa 87.1 kDa	No	0
CDK11B-201 ENSP00000485705 ENST00000626918	A0A0D9SEI3 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	772 aa 89.4 kDa	No	0
CDK11B-202 ENSP00000485937 ENST00000629289	A0A0D9SER5 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	783 aa 90.2 kDa	No	0
CDK11B-203 ENSP00000485849 ENST00000629312	A0A0D9SEN2 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	785 aa 90.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.