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Several endometrial and ovarian cancers along with a few cervical, colorectal, breast, testis, stomach and pancreatic cancers displayed moderate to strong cytoplasmic and/or membranous positivity with additional nuclear staining in some cases. Remaining cancer cells were weakly stained or negative.
A majority of cancer cells showed moderate to strong cytoplasmic staining. Carcinoids as well as most gliomas and testicular cancers were negative.
GENE INFORMATION
Gene name
DPP3
Synonyms
Description
Dipeptidyl-peptidase 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
