Tissue expression of DPP3 - Summary - The Human Protein Atlas

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DPP3

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DPP3
Gene description	Dipeptidyl-peptidase 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA035780 , HPA035781
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DPP3
Synonyms
Description	Dipeptidyl-peptidase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	66480013 - 66509657
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000254986 (version 83.38)
Entrez gene	10072
UniProt	Q9NY33 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY33
Antibodypedia	DPP3 antibodies

PROTEIN BROWSER

DPP3-001	DPP3-002	DPP3-003	DPP3-005	DPP3-006	DPP3-007	DPP3-009	DPP3-015	DPP3-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPP3-001 ENSP00000435284 ENST00000532677	G3V1D3 [Direct mapping] Dipeptidyl peptidase 3; HCG2016942, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008239 [dipeptidyl-peptidase activity] Show all	756 aa 84.3 kDa	No	0
DPP3-002 ENSP00000432782 ENST00000531863	G3V180 [Direct mapping] Dipeptidyl peptidase 3; HCG2016942, isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008239 [dipeptidyl-peptidase activity] Show all	757 aa 84.4 kDa	No	0
DPP3-003 ENSP00000436941 ENST00000530165	Q9NY33 [Direct mapping] Dipeptidyl peptidase 3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0008270 [zinc ion binding] GO:0070062 [extracellular exosome] Show all	707 aa 79.3 kDa	No	0
DPP3-005 ENSP00000440502 ENST00000541961	Q9NY33 [Direct mapping] Dipeptidyl peptidase 3 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008239 [dipeptidyl-peptidase activity] GO:0008270 [zinc ion binding] GO:0070062 [extracellular exosome] Show all	737 aa 82.6 kDa	No	0
DPP3-006 ENSP00000437101 ENST00000532019	E9PNX5 [Direct mapping] Dipeptidyl peptidase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.7 kDa	No	0
DPP3-007 ENSP00000436820 ENST00000531314	E9PQF2 [Direct mapping] Dipeptidyl peptidase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.3 kDa	No	0
DPP3-009 ENSP00000431606 ENST00000526515	E9PKK8 [Direct mapping] Dipeptidyl peptidase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 19.3 kDa	No	0
DPP3-015 ENSP00000434518 ENST00000533725	E9PQ14 [Direct mapping] Dipeptidyl peptidase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	177 aa 19.8 kDa	No	0
DPP3-017 ENSP00000432618 ENST00000531354	E9PPK9 [Direct mapping] Dipeptidyl peptidase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		201 aa 22.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.